Plasma level of alpha-synuclein oligomers as a biomarker for isolated rapid eye movement sleep behavior disorder diagnosis and progression: a prospective cohort study.

Compared to patients with higher o-α-syn levels, the risk of disease-free conversion for iRBD patients was 2.012 times higher for individuals with a low levels of o-α-syn, while the p -value from the Log-rank test only reached borderline significance (adjusted HR = 2.012, 95% CI: 0.923–4.386, p = 0.079).

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