Drug resistant pancreatic cancer cells exhibit altered biophysical interactions with stromal fibroblasts in imaging studies of 3D co-culture models.

2 D) also increases over time, where again the change is dramatic in the PANC1 + MRC5 AOCs (increase in mean size of about 4 times in 24 h, p < 0.01) and less so in the PANC1 + PSC AOCs (factor of 1.8 increase with modest significance of p = 0.02 over the same time period).

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