Elevated basophil count is associated with increased risk of endometriosis.

When stratifying women with endometriosis by diagnosis ascertainment type (self-reported vs hospital-based diagnosis) in the UKBB, a significant association with basophil counts was observed for self-reported endometriosis diagnosis for women with basophil counts of 0.01–0.04 (OR = 1.25, 95% CI (1.03–1.50)) and basophil counts of >0.04 (OR = 1.28, 95% CI (1.05–1.56), P trend = 0.013), and a marginally significant association for hospital-made diagnoses (OR = 1.10, 95% CI (0.94–1.28) for women with basophil counts of 0.01–0.04; and OR = 1.17, 95% CI (1.00–1.37) for women with counts above the upper tercile, P trend = 0.047).

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When the analysis was restricted to surgically confirmed endometriosis in the UKBB, women whose basophil levels were between 0.01 and 0.04 had a 12% increased odds of endometriosis (OR = 1.12, 95% CI (0.97–1.30)); however, the association results did not reach statistical significance.

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