Sparsentan ameliorates glomerular hypercellularity and inflammatory-gene networks induced by IgA1-IgG immune complexes in a mouse model of IgA nephropathy.

The EIC-induced upregulation of the genes examined was ameliorated by sparsentan at both doses, with a clear trend for a lessening of expression following sparsentan treatment compared with that in control mice ( Fig. 6 ).

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