The low-density lipoprotein receptor contributes to carotenoid homeostasis by regulating tissue uptake and fecal elimination.

Circulating β-carotene levels remained higher in Bco1 −/− Ldlr −/− mice in comparison to Bco1 −/− mice ( Figure 6 D), while the biliary content of β-carotene followed the opposite pattern but failed to reach statistical significance ( Figure 6 E). 3.6 SR-BI does not contribute to the intestinal elimination of β-carotene The absence of LDLR does not completely prevent fecal β-carotene disposal, suggesting that other carotenoid transporters could contribute to this process.

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Cumulative fecal β-carotene elimination followed an increasing trend in Bco1 −/− mice compared to Bco1 −/− Ldlr −/− mice ( Figure 6 C).

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