Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling.

We observed that 4 neurotoxic astrocyte-associated transcripts exhibited augmented upregulation following MPTP administration in Ripk3 -2xFV fl/fl Aldh1l1 Cre+ mice, including Ccl5 , Cd14 , Cxcl10 , and Psmb8 , while 2 others exhibited trends toward increased expression that did not reach statistical significance ( Cd109 , H2-D1 ) ( Figure 2F ).

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