The histone methyltransferase SUV420H2 regulates brown and beige adipocyte thermogenesis.

This was consistent with larger adipocytes observed in both iBAT and iWAT of H2KO mice ( Figure 3C ), with a shift of reduced smaller adipocyte and reciprocally increased larger adipocyte numbers in both iBAT and iWAT of cold-challenged H2KO mice, although the increase of larger adipocyte numbers in iWAT did not reach statistical significance ( Figure 3D ).

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