Molecular basis and functional consequences of the interaction between the base excision repair DNA glycosylase NEIL1 and RPA.

The effect of NEIL1 addback did not reach statistical significance in this cell line ( p = 0.0781), however the overall trend matched our observations in other cell lines.

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Consistent with the results in U2OS, complementation with the WT NEIL1 that is able to bind RPA results in a slight trend towards increased in NER capacity, whereas complementation with the empty vector or the RPA-binding-deficient NEIL1 mutant did not ( Fig.

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