Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78/IRE1α/JNK axis induced apoptosis and endoplasmic reticulum stress.

On the other hand, we also determined the effect of MPs on the reproductive performance of pregnant mice, and our results showed that: Compared with the control group, the fetal and placental weights of pregnant mice at higher MPs doses (50 mg/kg and 100 mg/kg) were significantly reduced ( P < .05), and the total number of fetuses in each group showed a trend of gradually decreasing with the increase of MPs concentration, but there was no significant difference among the groups.

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