The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription.

Pseudotyped HIV-1 virions bearing the Env proteins of amphotropic murine leukemia virus (A-MLV) exhibited an average NERT activity approximately 43% that of virions bearing HIV-1 Env ( Fig 4A ), though this activity did not reach statistical significance owing to high variability between experiments ( Fig 4A , right panel).

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