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MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer.

Endocrinology · 2024 · PMC11398899 · PMID 39253786

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MED12 Knockdown Decreases AR Activity In the high-throughput RNA-seq data, we observed that MED12 knockdown strongly deregulates individual genes within the hallmark androgen response gene set in AR-positive cell lines, although the gene set as a whole did not reach statistical significance [Supplementary Fig.

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