showed a trendp = 0.058
Patients who contracted COVID-19 showed a trend of lower spike IgG titers in the sampling prior to disease compared to those who remained uninfected (p = 0.058, Fig. 2 F), possibly indicating waning of protective antibody levels resulting in increased susceptibility to infection. 3.4 Generation of spike-specific memory B-cells occurs after vaccination Out of the 17 subjects who were sampled at baseline, all had undetectable spike-specific switched memory B-cells (MBC), except one CKD patient and four controls, who expressed possibly false positive low levels (p < 0.05).