PDGF-BB overexpression in p53 null oligodendrocyte progenitors increases H3K27me3 and induces transcriptional changes which favor proliferation.

By filtering for highly significant genes enriched in proneural glioma, we noted the upregulation of several cell cycle controlling genes ( Cdc7,Cdc25a, Atad5 ), in BB-p53n OPCs and the down-regulation of OPC markers ( Nkx2-2, Gpr17 ) ( Fig. 3 E).

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In addition, even though the GSEA analysis of OPC differentiation gene set showed insignificant enrichment (data not shown), the transcript levels of genes involved in OPC differentiation such as: Prmt5 , an arginine methyl transferase important for OPC differentiation [ 19 ] and Erbb2 , a tyrosine kinase involved in OPC differentiation [ 38 ], showed a trend towards increased expression after 48 h treatment with EZH2i (Supp.

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