Understanding the Molecular Mechanism of Anesthesia: Effect of General Anesthetics and Structurally Similar Non-Anesthetics on the Properties of Lipid Membranes.

Nevertheless, among the three membrane dimensions considered, it is the area per lipid that not only shows a clear trend with both the nature (i.e., anesthetics vs. non-anesthetics) of the solute and the pressure and hence changes consistently with both the anesthetic effect and its pressure reversal, but it is also in a clear causal relation both with the distribution of the solute molecules along the membrane normal and with the further changes discussed in the following subsections, which eventually trigger the anesthetic effect. 3.3.

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