Prognostic implications of HIF-1α expression in anal squamous cell carcinoma treated with intensity-modulated radiotherapy (IMRT).

In contrast, tumors with positive p16 status exhibited a substantial improvement in OS (HR: 0.2), although the effects on DFS and LRRFS did not reach statistical significance (HRs: 0.36 and 0.28, respectively) ( Table 2 ).

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