49 Furthermore, a meta‐analysis encompassing 26 studies indicated that individuals with CRC exhibited higher average copper levels compared with controls, although this disparity did not reach statistical significance. 50 Copper‐related complexes inhibit tumor cell proliferation by inhibiting the nuclear factor kappa‐B (NF‐κB) pathway. 51 Shao et al. 52 examined the association between the expression of cuproptosis‐related molecules and CRC, finding that the levels of cuproptosis‐related molecules were linked to tumor node metastasis (TNM) stage, pathological characteristics, tumor immune microenvironment, and drug resistance in CRC patients.
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