The effectiveness of phytosomal curcumin on clinical and laboratory parameters of patients with multiple trauma admitted to the intensive care unit: a double-blind randomized placebo-controlled trial.

In line with prior research [ 55 , 56 ], the current study also revealed that while phytosomal curcumin supplementation had a favorable impact on some clinical and laboratory parameters, its effect on reducing mortality did not reach statistical significance.

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Results After seven days of intervention, the mean increase from baseline in the Glasgow coma scale (GCS) score was significantly higher in the curcumin compared with the placebo group ( P -value: 0.028), while the reduction in the APACHE-II score in the curcumin group was greater than that the placebo group in a marginally non-significant fashion ( P -value: 0.055).

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