Advanced Quantitative MRI Unveils Microstructural Thalamic Changes Reflecting Disease Progression in Multiple Sclerosis.

Compared with HCs, patients with active RRMS had an accelerated rate of increase in qT1 values [ MD-ApC : 0.74 (95% CI 0.33–1.15); p = 0.0005]; the difference in thalamic atrophy rates approached but did not reach statistical significance [ MD-ApC : −0.71 (95% CI −1.46 to 0.04); p = 0.066].

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