CYP2C9, CYP3A and CYP2C19 metabolize Δ9-tetrahydrocannabinol to multiple metabolites but metabolism is affected by human liver fatty acid binding protein (FABP1).

However, stepwise regression analysis showed a trend towards better correlation when CYP2C19 activity was added and (+)-N-3-benzylnirvanol inhibited portion of 11-OH-THC formation in livers in which CYP2C19 activity is high ( Fig. 6 ).

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