Vaccine induced mucosal and systemic memory NK/ILCs elicit decreased risk of SIV/SHIV acquisition.

Env- reactive IL-13 + ILC2 showed a trend of positive correlation ( Figure 2I ) while IL-17 + ILC3 ( Figure 2J ) positively correlated with number of challenges in SIV ΔV1-vaccinated animals.

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We observed a positive correlation between memory-like mucosal NK cells and V2-specific ADCC for the SIV ΔV1 vaccine ( Figure 1K ) and a positive trend for the WT and ΔV1 HIV vaccines ( Supplementary Figure S1F ), suggesting memory-like NK cells might promote V2-specific ADCC and thereby contribute to protective efficacy.

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