The oral intake of specific Bioactive Collagen Peptides (BCP) improves gait and quality of life in canine osteoarthritis patients-A translational large animal model for a nutritional therapy option.

On the other hand, there was a highly significant improvement in PVF in the BCP group (p < 0.001), an effect that was significant compared to the PLA group (p = 0.012) or the unaffected limb of the same group (p < 0.001).

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When comparing the RPD percentages in the gait parameters of the affected and the unaffected limbs, the PLA group showed a decrease, i.e., clinical deterioration, in all three parameters measured in the affected limb during the 12-week period, which was significant for PVF ( Fig 3 ), close to significance for VI (p = 0.072), or not significant (DSP).

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In the BCP group, the treadmill examination also showed a trend towards an increase in VI (p = 0.157) but no effect for DSP (p = 0.643).

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They showed partially significant improvements in the evaluated gait analysis parameters VI, PVF, and symmetry indices as kinetic measures, and DSP, determined in the affected and contralateral limbs in dogs after 12 weeks of oral BCP intake.

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