Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns.

However, the differences in the transcription levels of S100A9, ITGAM, TLR8, and SPI1 did not reach statistical significance between the two groups (S100A9, p=0.2086; ITGAM, p=0.62; TLR8, p=0.4557; SPI1, p=0.3829). 3.8 Screening of small molecule drugs Twenty-one potential drugs for treating burn patients were identified using DGIdb ( Supplementary Table S2 ).

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S100A8 was not only significantly upregulated and identified to be prognosis-related among the hub DEGs but also exhibited an increasing trend in clinical blood samples.

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