ChIP assays of the subregions in SNCA intron 1, ChIP1 and ChIP2, showed a trend towards reduced binding of MeCP2 in PD compared to healthy controls, but again, the small group numbers prevented statistical analysis (Fig. 2 F).
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The Alpha-Synuclein Gene (SNCA) is a Genomic Target of Methyl-CpG Binding Protein 2 (MeCP2)-Implications for Parkinson's Disease and Rett Syndrome.
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