Mid-pass whole-genome sequencing in a Malagasy cohort uncovers body composition associations.

Additionally, the lead variant associated with FEV1 max, chr5_43372087_A_G/rs11950040, is also common in European-ancestry cohorts from the 1000 Genomes and has a nominally significant association with peak expiratory flow in a multi-ancestry European cohort. 38 Although we combined the cohort across sites due to low sample sizes, the slight genetic differentiation and varying environmental or selective pressures across the sites suggest that deeper sampling and investigations in each region could identify group-specific genetic associations with traits of interest.

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