Body Composition, Sarcopenia, and Serum Myokines in Acromegaly: A Narrative Review.

They showed that LBM was significantly correlated with leucine incorporation (R 2 =0.62, P <0.001) and leucine oxidation (R 2 =0.37, P <0.001) in healthy and patients with acromegaly.[ 24 ] Despite greater leucine incorporation in patients with acromegaly than in controls, differences after adjusting for LBM did not reach statistical significance.[ 24 ] Leucine oxidation was not different between the two groups, either unadjusted or adjusted, for LBM or body cell mass.[ 24 ] DXA scanning revealed a significant reduction in LBM in patients with acromegaly (61.3 [40.9–76.3] vs. 58.7 kg [39.8–71.5], P <0.05) after long-term treatment.[ 24 ] In

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