Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.

Key apoptotic genes, such as Casp3, Card10, Bid , and Bcl-2 , were at a significantly higher level of expression in SHAM infected mice ( Figures 5I–K ), while other proapoptotic genes, like Bax, Bad, Casp3 , and Fas , showed a trend of being higher ( Supplementary Figures 5G–J ), in addition to other differentially expressed apoptosis related genes as plotted via heatmap ( Figure 5G ; Supplementary Figure 5F ).

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