In conclusion, our results showed that the 2′MOE chemistry seems to be the most promising chemistry in terms of efficacy, distribution, and safety for photoreceptor cells, and overall both 2′MOE and 2′OMe have a similar profile, although 2′MOE showed a trend towards higher efficacy for the majority of the targets.
← all excerpts
Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina.
1
—
—