The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease.

Furthermore, using cut-off values to rule-out significant/advanced fibrosis (FIB-4 ≥1.3, LSM ≥5.8 kPa and LSM ≥8 kPa), we observed a significant trend of higher proportion of H . pylori -positive subjects with FIB-4 ≥1.3 (44%, p 0.04), LSM ≥5.8 kPA (66%, p 0.027), and LSM ≥8 kPa (39%, p 0.013) compared to H . pylori -negative patients (FIB-4 ≥1.3 21%; LSM ≥5.8 kPa 40%, LSM ≥8 kPa 13%) ( Fig 3A and 3B ).

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