nominally significantp < 0.05
Causal effects of SGLT2 inhibition on gut microbiota and metabolites The IVW method revealed 152 nominally significant associations (p < 0.05) between SGLT2 inhibition and gut microbiota, 173 nominal associations with 249 circulating metabolites, and 220 nominal associations with 486 metabolites ( Figures 3 – 5 ; Supplementary Table S4 ). 3.4.