Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction.

Aortic peroxisome proliferator-activated receptor-alpha (Ppar-α) was significantly higher in Ccdc93 +/- mice as compared to littermate controls (1.28-fold higher, P = 0.018, Fig 4G and 4H ), and low-density lipoprotein receptor-related protein (Lrp1) protein expression was higher but did not reach statistical significance (1.17-fold higher, P = 0.083, Fig 4G and 4I ).

also in 111,027 other papers