Intriguingly, while CXCR2 alteration did not affect dendritic cell, T cell, NK cell, and NKT cell infiltration, it showed a trend towards reducing neutrophil infiltration, particularly in acute colonic inflammation, indicating CXCR2’s primary involvement in neutrophil-mediated inflammation in UC ( 32 ).
← all excerpts
CXCR1 and CXCR2 are potential neutrophil extracellular trap-related treatment targets in ulcerative colitis: insights from Mendelian randomization, colocalization and transcriptomic analysis.
1
—
—