Overcoming drug resistance of cancer cells by targeting the FGF1/FGFR1 axis with honokiol or FGF ligand trap.

Results that did not reach statistical significance, with a p -value greater than 0.05, were marked as “ns” (not significant). 3 Results 3.1 Honokiol inhibits FGF-induced cell signaling through direct interaction with the kinase domain of FGFR1 Here, we examined the effect of honokiol on FGFR1 activity, building on previous work demonstrating its role in EGFR inhibition ( Song et al., 2016 ).

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