Super-resolution ultrasound imaging reveals temporal cerebrovascular changes with disease progression in female 5×FAD mouse model of Alzheimer's disease: correlation with pathological impairments.

The densities of BBB leakage sites in the retrosplenial and visual cortices did not significantly change between 7 and 12 months ( p = 0.452 and p = 0.743, respectively), whereas the hippocampus showed a trend towards increased leakage at 12 months ( p = 0.069, two-way ANOVA, Fig. 8 d).

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In the retrosplenial cortex, both non-Tg and 5×FAD mice exhibited a decreasing trend in vascular density, with significantly lower levels at 12 months compared to 4 and 7 months, indicating an age-related reduction in this region for both groups.

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