Comparative analysis of thermal adaptations of extremophilic prolyl oligopeptidases.

Additionally, although we do see an increasing trend of hydrophobic residues with temperature ( Fig. 5 ), the trend is driven by the increase in hydrophobic residues in mesophiles compared to psychrophiles, with thermophiles having similar proportions of hydrophobic residues to psychrophiles.

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In fact, none of the hydrophobic residues show a significant trend with temperature, and, in general, these proteins appear not to follow the trends reported by Berezovsky et al.

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