Impact of Dose-Escalated Chemoradiation on Pathological Complete Response in Patients with Locally Advanced Rectal Cancer.

The ypCR rate achieved was 25% versus 10.64% in favor of dose escalation, with no significant difference, but a trend toward significance ( p = 0.07).

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10.64%; p = 0.07), showing a trend towards significance, and a lower rate of no response to the treatment (38.64% vs. 61.36%; p = 0.11).

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Although the RT dose did not reach statistical significance, its OR ( Table 4 ) showed that, with dose escalation, more than double the complete pathological responses can be obtained compared to the standard dose (25% vs. 10.64%), with the results not being statistically significant due to the sample size limitation ( p = 0.07).

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