Chitosan/Sodium Alginate Hydrogel for the Release of Berberine as an Algae Suppressant: RSM Optimization and Analysis of Sustained Release Characteristics.

With the increase of chitosan content (X 1 ) and anhydrous calcium chloride content (X 3 ), the inhibition rate of berberine sustained-release microsphere materials on Microcystis aeruginosa showed a trend of increasing first and then decreasing; that is, in the preparation process of sustained-release microsphere materials, too high or too low chitosan content (X 1 ) and anhydrous calcium chloride content (X 3 ) will lead to a decrease in its inhibition rate.

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