HLA-A, -B, -C and -DRB1 Association with Autism Spectrum Disorder Risk: A Sex-Related Analysis in Italian ASD Children and Their Siblings.

Notably, the frequency of the HLA-C*04 allele was lower in both mASD (14.6%) ( p = 0.04, p c = 0.52 OR: 0.7; 95%CI: 0.5–1.0) and fASD (14.6%) compared to HC, although in the latter case, differences did not reach statistical significance ( p = 0.27) ( Figure 3 B, Table S3 ).

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