An 8-SNP LDL Cholesterol Polygenic Score: Associations with Cardiovascular Risk Traits, Familial Hypercholesterolemia Phenotype, and Premature Coronary Heart Disease in Central Romania.

These positive correlations were reinforced by a notable trend of increasing eLDLC levels and DLCN scores across wPRS deciles ( Figure 1 C–F).

also in 2,105 other papers

Additionally, the Jonckheere–Terpstra test indicated a significant trend, demonstrating that wPRS values increase significantly with each DLCN score category ( Figure 6 A).

also in 6,185 other papers

In examining the predictive value of wPRS for FH likelihood, we observed an increasing trend of wPRS across DLCN categories ( Figure 6 A).

also in 37,734 other papers

Similarly, a significant association was observed between wPRS and the DLCN score in the overall cohort, with marginal significance noted in the PCHD and HC groups ( Supplementary Table S2 ).

also in 3,088 other papers

Statistical analysis revealed weak but marginally significant correlations between the PRSs and two major phenotypic aspects: eLDLC and DLCN scores.

also in 15,194 other papers