Assessing Receptor Activation in 2D and 3D Cultured Hepatocytes: Responses to a Single Compound and a Complex Mixture.

In our study, connexin 26, predominantly located in hepatocytes, and connexin 43 [ 82 ], expressed in non-parenchymal liver cells, both exhibited a similar trend of increased mRNA fold changes in 3D versus 2D cultures following exposure to dexamethasone; however, these changes did not reach statistical significance ( Cx26 p = 0.1108; Cx43 p = 0.0675).

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