Concerns have arisen regarding the effectiveness and duration of protection provided by first-generation COVID-19 vaccines, due to the emergence of new SARS-CoV-2 variants and a decreasing trend in antibody titers in vaccinated individuals over time [ 32 ].
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Effectiveness of COVID-19 Vaccines in People with Severe Mental Illness: A Systematic Review and Meta-Analysis.
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Limited evidence suggests a higher mortality risk among SMI patients compared to controls post vaccination, but the findings did not reach statistical significance.