A preliminary analysis of variants using the sequence data obtained in this study showed a trend toward increased minority variants and therefore greater genetic diversity in viral populations of the Culicoides -derived BTV compared to the BHK-derived BTV, but deep sequencing efforts would be needed to further elucidate increased diversity in Culicoides -derived BTV in relation to virulence.
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Increased Virulence of <i>Culicoides</i> Midge Cell-Derived Bluetongue Virus in IFNAR Mice.
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