Higher prevalence of poor prognostic markers at a younger age in adult patients with myelodysplastic syndrome - evaluation of a large cohort in India.

There were highly significant differences between Western studies (age ≥ 16 years, n = 17,228) and our study ( n = 842) with respect to all five clinical risk groups ; we had fewer patients in both low-risk groups (34% vs. 66%) and more patients in the intermediate-risk (24% vs. 17%) and both high-risk (41% vs. 17%) groups ( P = < 0.001) [ 12 , 16 , 18 , 50 – 52 ].

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Trisomy 8 was more common in S.E Asia than among our patients, its weighted average (14%, P = 0.05) trending towards significance although its frequency varied widely (4–20%) in individual studies.

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