Associations of Intermittent Hypoxia Burden with Gut Microbiota Dysbiosis in Adult Patients with Obstructive Sleep Apnea.

Therefore, based on diversity analysis, the overall structure of the gut microbiota in patients with OSA was significantly altered compared to healthy individuals, and there was a decreasing trend in alpha diversity indices, such as Sobs, Chao1, and Ace, with increasing OSA severity (P<0.05).

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By contrast, the Shannon index decreased in the OSA group, and the Simpson index showed an increasing trend which was synchronous with the increase in OSA severity but did not reach statistical significance.

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