Impact of mAb-FcRn affinity on IgG transcytosis across human well-differentiated airway epithelium.

When we adjust for the input dose, the cumulative fraction of mAb transcytosed over the first 4 days reached ~1-3% for all three mAbs at the high input dose ( Figure 4C ); for CR3022 and CR3022-YTE but not CR3022-LS, the cumulative fraction transcytosed at the lower dose was even higher, although the difference did not reach statistical significance (see summary statistics in Supplementary Table S2 ).

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