Establishment of human pluripotent stem cell-derived cortical neurosphere model to study pathomechanisms and chemical toxicity in Kleefstra syndrome.

In our test system, when NPCs were treated with PQ, although the KS had an EC50 value of 61.14 μM, and the control was EC50 = 92.7 μM the difference did not reach statistical significance, and the dose-response curves were overlapping (Fig. 4 a; Table 1 ).

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