Furthermore, based on prognostic information of EGFR-mutant LUAD patients in GSE72094 , highly expressed HPRT1 showed a trend toward poor prognosis but there was no significant difference (Fig. 6 J).
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HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.
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