Progranulin protects against <i>Clostridioides difficile</i> infection by enhancing IL-22 production.

In a mild CDI model established with a dose of 1 × 10 8 CFUs of VPI 10,463 as described previously, 13 , 31 the survival rate of PGRN KO mice was lower than that of WT mice, but it did not reach statistical significance (Supplementary Figure 3).

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