Integrative multi-omics summary-based mendelian randomization identifies key oxidative stress-related genes as therapeutic targets for atrial fibrillation and flutter.

After the removal of associations with P HEIDI <0.01, a total of 346 CpG sites near 159 unique genes passed the marginal significance (P SMR < 0.05) ( Supplementary Table S2 ).

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In total, 83 associations were identified to be associated with AF at the nominally significant level (P SMR < 0.05, P HEIDI > 0.01) ( Supplementary Tab le S5 ).

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