Single-arm trial of neoadjuvant ipilimumab plus nivolumab with chemoradiotherapy in patients with resectable and borderline resectable lung cancer: the INCREASE study.

However, upregulation of HLA-DR was observed in patients who failed to achieve a pCR, and CD39+Treg frequencies showed a trend towards an increase throughout treatment and follow-up (non-significant).

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While CTLA-4 expression in CD8+T cells was low at baseline and stayed low, its expression in Tregs was notably higher and showed an increasing trend over time.

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