A clear trend of increased cross-reactivity was also observed comparing the SOSIP-NP cocktail immunized group to the mosaic SOSIP-NP immunized animals (this difference was statistically significant when the groups were directly compared with the Mann-Whitney U test, p = 0.0317).
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Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes.
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